uBlock has been my favourite web browser extension for years, removing all ads including video ads in YouTube for example.

Firefox and Safari are essentially your only options if you don't want a chromium based browser. Firefox is the only one of those that supports adblocking at the level uBlock Origin operates.

For Brave, Vivaldi, Opera GX, Edge etc, to continue to support uBO, they would need to maintain a fork of Chromium that supports Manifest v2 and it's likely that Google will continue to merge anti-user privacy stuff into Chromium that makes supporting v2 untenable at some point in the future.

cf. also: Google Chrome not supporting uBlock anymore is the result of Manifest v2 support being deprecated in favor of Manifest v3

Quoting uBlock official documentation:

uBlock works best on Firefox.